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Serious side effects from CBD alone are unlikely. But they can happen if CBD is taken along with THC or medications such as opioids or benzodiazepines. It’s unclear if CBD is the cause of the toxicity in these cases. ... Dosage, efficacy and safety of cannabidiol administration in adults: A systematic review of human trials.

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Research evidence shows that full-spectrum CBD preparations cause fewer side effects than purified CBD, which they think may be due to requiring smaller doses for similar therapeutic outcomes. The higher potency of full-spectrum CBD is speculated to be from the synergy between the plant’s many components, what researchers call the ...

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